Supplemental Fig. S1

Supplemental Fig. S1 Top: graphic representation of the TCF4 transcript NM_001083962: black bars represent introns, larger shapes with numbers inside represent the coding part of exons and their length in bps, smaller rectangles stand for 5’ and 3’ UTRs. The arrowhead shape of exons indicate that they include a codon requiring two further nucleotides from the adjacent exon to be completed, the arrow tail indicates that there is a codon requiring another nucleotide to be complete. Arrows indicate the rough positions of starting codons used in different transcripts.
Bottom: Organization of different TCF4 protein isoforms. White numbered rectangles indicate exons, shaded areas the location of important functional domains. The NLS domain is coded by exons 7 and 8. For clarity purpose, only three of the many isoforms are depicted. AD1 and AD2: activation domain 1 and 2; NLS nuclear localization signal; bHLH: basic helix-loop-helix domain.